Peripheral blood lymphocyte subset shifts in patients with untreated hematological tumors: evidence for systemic activation of the T cell compartment
LE Van den Hove, P Vandenberghe, SW Van Gool… - Leukemia research, 1998 - Elsevier
Flow cytometry immunophenotyping of peripheral blood lymphocyte subsets and
multivariate data-analytical techniques revealed that among untreated hemato-oncological
patients (n= 48) with lymphomas, acute and chronic myeloid and lymphocytic leukemias,
monoclonal gammopathy of undetermined significance, and multiple myeloma, 42% had
(nonmalignant) lymphocyte profiles clearly distinct from healthy donors. Notably, a similar
pattern of increased CD3+ CD57+, CD3+ HLA-DR+, CD3+ CD (16+ 56)+, CD4− CD8+ …
multivariate data-analytical techniques revealed that among untreated hemato-oncological
patients (n= 48) with lymphomas, acute and chronic myeloid and lymphocytic leukemias,
monoclonal gammopathy of undetermined significance, and multiple myeloma, 42% had
(nonmalignant) lymphocyte profiles clearly distinct from healthy donors. Notably, a similar
pattern of increased CD3+ CD57+, CD3+ HLA-DR+, CD3+ CD (16+ 56)+, CD4− CD8+ …