The perineuronal net component of the extracellular matrix in plasticity and epilepsy
PA McRae, BE Porter - Neurochemistry international, 2012 - Elsevier
During development the extracellular matrix (ECM) of the central nervous system (CNS)
facilitates proliferation, migration, and synaptogenesis. In the mature nervous system due to
changes in the ECM it provides structural stability and impedes proliferation, migration, and
synaptogensis. The perineuronal net (PN) is a specialized ECM structure found primarily
surrounding inhibitory interneurons where it forms a mesh-like structure around points of
synaptic contact. The PN organizes the extracellular space by binding multiple components …
facilitates proliferation, migration, and synaptogenesis. In the mature nervous system due to
changes in the ECM it provides structural stability and impedes proliferation, migration, and
synaptogensis. The perineuronal net (PN) is a specialized ECM structure found primarily
surrounding inhibitory interneurons where it forms a mesh-like structure around points of
synaptic contact. The PN organizes the extracellular space by binding multiple components …