Cellular senescence is historically associated with cancer suppression and aging. Recently,
the reach of the senescence genetic program has been extended to include the ability of
senescent cells to actively participate in tissue remodelling during many physiological
processes, including placental biology, embryonic patterning, wound healing, and tissue
stress responses caused by cancer therapy. Besides growth arrest, a significant feature of
senescent cells is their ability to modify their immediate microenvironment using a …