[HTML][HTML] Comparison of the capacity of β-cyclodextrin derivatives and cyclophanes to shuttle cholesterol between cells and serum lipoproteins
AE Christian, HS Byun, N Zhong, M Wanunu… - Journal of lipid …, 1999 - ASBMB
Previous studies from this laboratory have demonstrated that low concentrations of
cyclodextrins (< 1.0 mm), when added to serum, act catalytically as cholesterol shuttles to
accelerate the exchange of free cholesterol between cells and serum lipoproteins. As
cholesterol shuttles, cyclodextrins have the potential to serve as pharmacological agents for
modifying cholesterol metabolism. In the present study, we have quantitated the cholesterol-
shuttling capacity of a series of newly synthesized β-cyclodextrin derivatives (βCDs), with …
cyclodextrins (< 1.0 mm), when added to serum, act catalytically as cholesterol shuttles to
accelerate the exchange of free cholesterol between cells and serum lipoproteins. As
cholesterol shuttles, cyclodextrins have the potential to serve as pharmacological agents for
modifying cholesterol metabolism. In the present study, we have quantitated the cholesterol-
shuttling capacity of a series of newly synthesized β-cyclodextrin derivatives (βCDs), with …