Entry and exit mechanisms at the cis-face of the Golgi complex

A Lorente-Rodríguez… - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
A Lorente-Rodríguez, C Barlowe
Cold Spring Harbor perspectives in biology, 2011cshperspectives.cshlp.org
Vesicular transport of protein and lipid cargo from the endoplasmic reticulum (ER) to cis-
Golgi compartments depends on coat protein complexes, Rab GTPases, tethering factors,
and membrane fusion catalysts. ER-derived vesicles deliver cargo to an ER-Golgi
intermediate compartment (ERGIC) that then fuses with and/or matures into cis-Golgi
compartments. The forward transport pathway to cis-Golgi compartments is balanced by a
retrograde directed pathway that recycles transport machinery back to the ER. How …
Vesicular transport of protein and lipid cargo from the endoplasmic reticulum (ER) to cis-Golgi compartments depends on coat protein complexes, Rab GTPases, tethering factors, and membrane fusion catalysts. ER-derived vesicles deliver cargo to an ER-Golgi intermediate compartment (ERGIC) that then fuses with and/or matures into cis-Golgi compartments. The forward transport pathway to cis-Golgi compartments is balanced by a retrograde directed pathway that recycles transport machinery back to the ER. How trafficking through the ERGIC and cis-Golgi is coordinated to maintain organelle structure and function is poorly understood and highlights central questions regarding trafficking routes and organization of the early secretory pathway.
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