[HTML][HTML] Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization
M Dentice, JW Harney, C Curcio-Morelli… - Journal of biological …, 2006 - ASBMB
Thyroid hormone activation is catalyzed by two deiodinases, D1 and D2. Whereas D1 is a
stable plasma membrane protein, D2 is resident in the endoplasmic reticulum (ER) and has
a 20-min half-life due to selective ubiquitination and proteasomal degradation. Here we
have shown that stable retention explains D2 residency in the ER, a mechanism that is
nevertheless over-ridden by fusion to the long-lived plasma membrane protein, sodium-
iodine symporter. Fusion to D2, but not D1, dramatically shortened sodium-iodine symporter …
stable plasma membrane protein, D2 is resident in the endoplasmic reticulum (ER) and has
a 20-min half-life due to selective ubiquitination and proteasomal degradation. Here we
have shown that stable retention explains D2 residency in the ER, a mechanism that is
nevertheless over-ridden by fusion to the long-lived plasma membrane protein, sodium-
iodine symporter. Fusion to D2, but not D1, dramatically shortened sodium-iodine symporter …