[PDF][PDF] Lin28: primal regulator of growth and metabolism in stem cells

N Shyh-Chang, GQ Daley - Cell stem cell, 2013 - cell.com
Cell stem cell, 2013cell.com
In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and
influence mRNA translation, thereby regulating the self-renewal of mammalian embryonic
stem cells. Subsequent discoveries revealed that Lin28a and Lin28b are also important in
organismal growth and metabolism, tissue development, somatic reprogramming, and
cancer. In this review, we discuss the Lin28 pathway and its regulation, outline its roles in …
In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and influence mRNA translation, thereby regulating the self-renewal of mammalian embryonic stem cells. Subsequent discoveries revealed that Lin28a and Lin28b are also important in organismal growth and metabolism, tissue development, somatic reprogramming, and cancer. In this review, we discuss the Lin28 pathway and its regulation, outline its roles in stem cells, tissue development, and pathogenesis, and examine the ramifications for re-engineering mammalian physiology.
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