Molecular cloning, functional expression and chromosomal localization of a human homolog of the cyclic nucleotide‐gated ion channel of retinal cone photoreceptors
WP Yu, ME Grunwald, KW Yau - FEBS letters, 1996 - Wiley Online Library
WP Yu, ME Grunwald, KW Yau
FEBS letters, 1996•Wiley Online LibraryWe have cloned from human retina a cyclic nucleotide‐gated (CNG) ion channel that is
distinct from the one found in rod photoreceptors. This channel protein is highly homologous
to the CNG channel that recently has been cloned from bovine testis and kidney and has
been shown to be present i retinal cone photoreceptors. When expressed in human
embryonic kidney cells, the protein forms functional ion channels with properties broadly
similar to those described for the cloned bovine channel. The gene for this channel resides …
distinct from the one found in rod photoreceptors. This channel protein is highly homologous
to the CNG channel that recently has been cloned from bovine testis and kidney and has
been shown to be present i retinal cone photoreceptors. When expressed in human
embryonic kidney cells, the protein forms functional ion channels with properties broadly
similar to those described for the cloned bovine channel. The gene for this channel resides …
We have cloned from human retina a cyclic nucleotide‐gated (CNG) ion channel that is distinct from the one found in rod photoreceptors. This channel protein is highly homologous to the CNG channel that recently has been cloned from bovine testis and kidney and has been shown to be present i retinal cone photoreceptors. When expressed in human embryonic kidney cells, the protein forms functional ion channels with properties broadly similar to those described for the cloned bovine channel. The gene for this channel resides on chromosome 2.
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