[HTML][HTML] Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping
S Michalakis, J Reisert, H Geiger, C Wetzel… - Journal of biological …, 2006 - ASBMB
Olfactory receptor neurons (ORNs) employ a cyclic nucleotide-gated (CNG) channel to
generate a receptor current in response to an odorant-induced rise in cAMP. This channel
contains three types of subunits, the principal CNGA2 subunit and two modulatory subunits
(CNGA4 and CNGB1b). Here, we have analyzed the functional relevance of CNGB1 for
olfaction by gene targeting in mice. Electro-olfactogram responses of CNGB1-deficient
(CNGB1-/-) mice displayed a reduced maximal amplitude and decelerated onset and …
generate a receptor current in response to an odorant-induced rise in cAMP. This channel
contains three types of subunits, the principal CNGA2 subunit and two modulatory subunits
(CNGA4 and CNGB1b). Here, we have analyzed the functional relevance of CNGB1 for
olfaction by gene targeting in mice. Electro-olfactogram responses of CNGB1-deficient
(CNGB1-/-) mice displayed a reduced maximal amplitude and decelerated onset and …