Modulation of Erythrocyte Membrane Mechanical Function by β-Spectrin Phosphorylation and Dephosphorylation (∗)
S Manno, Y Takakuwa, K Nagao, N Mohandas - Journal of Biological …, 1995 - jbc.org
The mechanical properties of human erythrocyte membrane are largely regulated by
submembranous protein skeleton whose principal components are α-and β-spectrin, actin,
protein 4.1, adducin, and dematin. All of these proteins, except for actin, are phosphorylated
by various kinases present in the erythrocyte. In vitro studies with purified skeletal proteins
and various kinases has shown that while phosphorylation of these proteins can modify
some of the binary and ternary protein interactions, it has no effect on certain other …
submembranous protein skeleton whose principal components are α-and β-spectrin, actin,
protein 4.1, adducin, and dematin. All of these proteins, except for actin, are phosphorylated
by various kinases present in the erythrocyte. In vitro studies with purified skeletal proteins
and various kinases has shown that while phosphorylation of these proteins can modify
some of the binary and ternary protein interactions, it has no effect on certain other …
