[HTML][HTML] Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
Z Gao, J Zhang, I Kheterpal, N Kennedy… - Journal of Biological …, 2011 - ASBMB
SIRT1 is involved in the pathogenesis of obesity, diabetes, and aging. However, it is not
clear how SIRT1 activity is regulated by intracellular kinases in cells. In this study, we
investigated SIRT1 phosphorylation and protein degradation in response to JNK1 activation
in obese mice. Mouse SIRT1 is phosphorylated by JNK1 at Ser-46 (Ser-47 in human SIRT1),
which is one of the four potential residues targeted by JNK1. The phosphorylation induces a
brief activation of SIRT1 function and degradation of SIRT1 thereafter by the proteasome …
clear how SIRT1 activity is regulated by intracellular kinases in cells. In this study, we
investigated SIRT1 phosphorylation and protein degradation in response to JNK1 activation
in obese mice. Mouse SIRT1 is phosphorylated by JNK1 at Ser-46 (Ser-47 in human SIRT1),
which is one of the four potential residues targeted by JNK1. The phosphorylation induces a
brief activation of SIRT1 function and degradation of SIRT1 thereafter by the proteasome …