Gα12 overexpression induced by miR-16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells
KM Kim, CY Han, JY Kim, SS Cho, YS Kim, JH Koo… - Journal of …, 2018 - Elsevier
Background & Aims Hepatic stellate cells (HSCs) have a role in liver fibrosis. Guanine
nucleotide-binding α-subunit 12 (Gα 12) converges signals from G-protein-coupled
receptors whose ligand levels are elevated in the environment during liver fibrosis; however,
information is lacking on the effect of Gα 12 on HSC trans-differentiation. This study
investigated the expression of Gα 12 in HSCs and the molecular basis of the effects of its
expression on liver fibrosis. Methods Gα 12 expression was assessed by immunostaining …
nucleotide-binding α-subunit 12 (Gα 12) converges signals from G-protein-coupled
receptors whose ligand levels are elevated in the environment during liver fibrosis; however,
information is lacking on the effect of Gα 12 on HSC trans-differentiation. This study
investigated the expression of Gα 12 in HSCs and the molecular basis of the effects of its
expression on liver fibrosis. Methods Gα 12 expression was assessed by immunostaining …