The role of JNK proteins in metabolism
SN Vallerie, GS Hotamisligil - Science translational medicine, 2010 - science.org
SN Vallerie, GS Hotamisligil
Science translational medicine, 2010•science.orgThe stress-activated c-Jun amino-terminal kinase (JNK) plays a pivotal role in metabolic
conditions such as obesity, insulin resistance, and type 2 diabetes. Intricate tissue-specific
tweaking of JNK activity in preclinical models of metabolic diseases reveals a complex
interplay among local and systemic effects on carbohydrate and lipid metabolism. Synthesis
of these entangled effects illustrates that for JNK inhibitors to have therapeutic impact, they
must function in multiple cell types to modulate JNK activity.
conditions such as obesity, insulin resistance, and type 2 diabetes. Intricate tissue-specific
tweaking of JNK activity in preclinical models of metabolic diseases reveals a complex
interplay among local and systemic effects on carbohydrate and lipid metabolism. Synthesis
of these entangled effects illustrates that for JNK inhibitors to have therapeutic impact, they
must function in multiple cell types to modulate JNK activity.
The stress-activated c-Jun amino-terminal kinase (JNK) plays a pivotal role in metabolic conditions such as obesity, insulin resistance, and type 2 diabetes. Intricate tissue-specific tweaking of JNK activity in preclinical models of metabolic diseases reveals a complex interplay among local and systemic effects on carbohydrate and lipid metabolism. Synthesis of these entangled effects illustrates that for JNK inhibitors to have therapeutic impact, they must function in multiple cell types to modulate JNK activity.
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