Notch2 activation in the embryonic kidney depletes nephron progenitors

S Fujimura, Q Jiang, C Kobayashi… - Journal of the …, 2010 - journals.lww.com
Successive activation of Wnt4 and Notch2 generates nephrons from the metanephric
mesenchyme. Mesenchymal-to-epithelial transition requires Wnt4, and normal development
of the proximal nephron (epithelia of glomeruli and proximal tubules) requires Notch2. It is
unknown, however, whether Notch2 dictates the fate of the proximal nephron directly. Here,
we generated a mutant strain of mice with activated Notch2 in Six2-containing nephron
progenitor cells of the metanephric mesenchyme. Notch2 activation did not skew the cell fate …