Structure and function of mammalian DNA ligases
AE Tomkinson, ZB Mackey - Mutation Research/DNA Repair, 1998 - Elsevier
DNA joining events are required for the completion of DNA replication, DNA excision repair
and genetic recombination. Five DNA ligase activities, I–V, have been purified from
mammalian cell extracts and three mammalian LIG genes, LIG1, LIG3 and LIG4, have been
cloned. During DNA replication, the joining of Okazaki fragments by the LIG1 gene product
appears to be mediated by an interaction with proliferating cell nuclear antigen (PCNA). This
interaction may also occur during the completion of mismatch, nucleotide excision and base …
and genetic recombination. Five DNA ligase activities, I–V, have been purified from
mammalian cell extracts and three mammalian LIG genes, LIG1, LIG3 and LIG4, have been
cloned. During DNA replication, the joining of Okazaki fragments by the LIG1 gene product
appears to be mediated by an interaction with proliferating cell nuclear antigen (PCNA). This
interaction may also occur during the completion of mismatch, nucleotide excision and base …