Multiple hypersensitivity to mutagens in a cell strain (46BR) derived from a patient with immuno-deficiencies
IA Teo, CF Arlett, SA Harcourt, A Priestley… - Mutation Research …, 1983 - Elsevier
Abstract 46BR is a fibroblast cell strain established from an individual with
hypogammaglobulinaemia. The cells unique in showing hypersensitivity to the lethal effects
of a wide range of DNA-damaging agents. Thus they are hypersensitive to γ-and 254-nm UV-
irradiation and show a limited capacity to repair potentially lethal γ-irradiation damage when
compared with fibroblasts from normal individuals. A slight hypersensitivity to mitomycin C
was also revealed but we were not able to discriminate 46BR from normals with 4 …
hypogammaglobulinaemia. The cells unique in showing hypersensitivity to the lethal effects
of a wide range of DNA-damaging agents. Thus they are hypersensitive to γ-and 254-nm UV-
irradiation and show a limited capacity to repair potentially lethal γ-irradiation damage when
compared with fibroblasts from normal individuals. A slight hypersensitivity to mitomycin C
was also revealed but we were not able to discriminate 46BR from normals with 4 …