[HTML][HTML] The osteopontin-CD44 survival signal involves activation of the phosphatidylinositol 3-kinase/Akt signaling pathway
YH Lin, HF Yang-Yen - Journal of Biological Chemistry, 2001 - ASBMB
We have recently demonstrated that the gene encoding the osteopontin (OPN) protein is
activated both by interleukin-3 and granulocyte-macrophage colony-stimulating factor
signaling pathways and that, through binding to the cell surface receptor CD44, OPN
contributes to the survival activities of interleukin (IL)-3 and GM-CSF (Lin, Y.-H., Huang, C.-
J., Chao, J.-R., Chen, S.-T., Lee, S.-F., Yen, JJ-Y., and Yang-Yen, H.-F.(2000) Mol. Cell. Biol.
20, 2734–2742). In this report, we demonstrate that the CD44-binding domain of OPN …
activated both by interleukin-3 and granulocyte-macrophage colony-stimulating factor
signaling pathways and that, through binding to the cell surface receptor CD44, OPN
contributes to the survival activities of interleukin (IL)-3 and GM-CSF (Lin, Y.-H., Huang, C.-
J., Chao, J.-R., Chen, S.-T., Lee, S.-F., Yen, JJ-Y., and Yang-Yen, H.-F.(2000) Mol. Cell. Biol.
20, 2734–2742). In this report, we demonstrate that the CD44-binding domain of OPN …