Targeting the cancer kinome through polypharmacology

ZA Knight, H Lin, KM Shokat - Nature Reviews Cancer, 2010 - nature.com
ZA Knight, H Lin, KM Shokat
Nature Reviews Cancer, 2010nature.com
Kinase inhibitors are the largest class of new cancer drugs. However, it is already apparent
that most tumours can escape from the inhibition of any single kinase. If it is necessary to
inhibit multiple kinases, how do we choose which ones? In this Opinion article, we discuss
some of the strategies that are currently being used to identify new therapeutic combinations
of kinase targets.
Abstract
Kinase inhibitors are the largest class of new cancer drugs. However, it is already apparent that most tumours can escape from the inhibition of any single kinase. If it is necessary to inhibit multiple kinases, how do we choose which ones? In this Opinion article, we discuss some of the strategies that are currently being used to identify new therapeutic combinations of kinase targets.
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