Serum interleukin-17 and its relationship to angiogenic factors in multiple myeloma
MG Alexandrakis, CA Pappa, S Miyakis… - European journal of …, 2006 - Elsevier
BACKGROUND: Interleukin-17 (IL-17) is a CD4 T-cell-derived mediator of angiogenesis that
stimulates vascular endothelial cell migration and regulates the production of a variety of
proangiogenic factors, such as tumor necrosis factor-α (TNF-α) and vascular endothelial cell
growth factor (VEGF). Angiogenesis is implicated in the progression of multiple myeloma
(MM). METHODS: We measured serum levels of IL-17, TNF-α, and VEGF, as well as
microvessel density (MVD) in 40 untreated MM patients. RESULTS: Levels of IL-17 in the …
stimulates vascular endothelial cell migration and regulates the production of a variety of
proangiogenic factors, such as tumor necrosis factor-α (TNF-α) and vascular endothelial cell
growth factor (VEGF). Angiogenesis is implicated in the progression of multiple myeloma
(MM). METHODS: We measured serum levels of IL-17, TNF-α, and VEGF, as well as
microvessel density (MVD) in 40 untreated MM patients. RESULTS: Levels of IL-17 in the …