[HTML][HTML] The role of antigen presenting cells in multiple sclerosis

EML Chastain, SD d'Anne, JM Rodgers… - Biochimica et Biophysica …, 2011 - Elsevier
EML Chastain, SD d'Anne, JM Rodgers, SD Miller
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2011Elsevier
Multiple sclerosis (MS) is a debilitating T cell mediated autoimmune disease of the central
nervous system (CNS). Animal models of MS, such as experimental autoimmune
encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus-induced
demyelinating disease (TMEV-IDD) have given light to cellular mechanisms involved in the
initiation and progression of this organ-specific autoimmune disease. Within the CNS,
antigen presenting cells (APC) such as microglia and astrocytes participate as first line …
Multiple sclerosis (MS) is a debilitating T cell mediated autoimmune disease of the central nervous system (CNS). Animal models of MS, such as experimental autoimmune encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) have given light to cellular mechanisms involved in the initiation and progression of this organ-specific autoimmune disease. Within the CNS, antigen presenting cells (APC) such as microglia and astrocytes participate as first line defenders against infections or inflammation. However, during chronic inflammation they can participate in perpetuating the self-destructive environment by secretion of inflammatory factors and/or presentation of myelin epitopes to autoreactive T cells. Dendritic cells (DC) are also participants in the presentation of antigen to T cells, even within the CNS. While the APCs alone are not solely responsible for mediating the destruction to the myelin sheath, they are critical players in perpetuating the inflammatory milieu. This review will highlight relevant studies which have provided insight to the roles played by microglia, DCs and astrocytes in the context of CNS autoimmunity.
Elsevier