[HTML][HTML] PLA2R Autoantibodies and PLA2R Glomerular Deposits in Membranous Nephropathy

H Debiec, P Ronco - New England Journal of Medicine, 2011 - Mass Medical Soc
H Debiec, P Ronco
New England Journal of Medicine, 2011Mass Medical Soc
To the Editor: Membranous nephropathy is a common cause of the nephrotic syndrome in
adults. Treatment is controversial and challenging because of the heterogeneity of the
disease and a lack of reliable biomarkers. 1, 2 M-type phospholipase A2 receptor (PLA2R)
was recently identified as a major target antigen involved in idiopathic membranous
nephropathy in adults. 3 Circulating autoantibodies against PLA2R were found in 70 to 80%
of patients with idiopathic membranous nephropathy but not in those with secondary …
To the Editor: Membranous nephropathy is a common cause of the nephrotic syndrome in adults. Treatment is controversial and challenging because of the heterogeneity of the disease and a lack of reliable biomarkers.1,2 M-type phospholipase A2 receptor (PLA2R) was recently identified as a major target antigen involved in idiopathic membranous nephropathy in adults.3 Circulating autoantibodies against PLA2R were found in 70 to 80% of patients with idiopathic membranous nephropathy but not in those with secondary membranous nephropathy or other renal diseases. It has been suggested that the serum level of PLA2R autoantibody . . .
The New England Journal Of Medicine