Abnormal neuronal aggregation of α-synuclein is implicated in the development of many
neurological disorders, including Parkinson disease and dementia with Lewy bodies. Glial
cells also show extensive α-synuclein pathology and may contribute to disease progression.
However, the mechanism that produces the glial α-synuclein pathology and the interaction
between neurons and glia in the disease-inflicted microenvironment remain unknown. Here,
we show that α-synuclein proteins released from neuronal cells are taken up by astrocytes …