Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus
DJ Rader - The American journal of medicine, 2007 - Elsevier
Abdominal obesity contributes to insulin resistance, a metabolic abnormality linked to the
development of type 2 diabetes mellitus and cardiovascular disease (CVD). Insulin
resistance generally precedes the development of type 2 diabetes. Currently, an estimated
10 million US adults have diabetes and another 25 million have impaired glucose tolerance
(IGT), an intermediate step between insulin resistance and diabetes. The pathophysiologic
mechanisms known to increase CVD risk in individuals with insulin resistance include …
development of type 2 diabetes mellitus and cardiovascular disease (CVD). Insulin
resistance generally precedes the development of type 2 diabetes. Currently, an estimated
10 million US adults have diabetes and another 25 million have impaired glucose tolerance
(IGT), an intermediate step between insulin resistance and diabetes. The pathophysiologic
mechanisms known to increase CVD risk in individuals with insulin resistance include …