[HTML][HTML] Immunohistochemical prediction of brain metastases in patients with advanced breast cancer: the role of Rad51
K Sosińska-Mielcarek, R Duchnowska, P Winczura… - The Breast, 2013 - Elsevier
K Sosińska-Mielcarek, R Duchnowska, P Winczura, A Badzio, H Majewska, J Lakomy…
The Breast, 2013•ElsevierBackground There are no clinically useful biomarkers predictive of brain metastases (BM) in
breast cancer. In this study, we investigated the correlation between expression of selected
proteins in the primary tumor and the risk of BM in patients with metastatic breast cancer
(MBC). Methods The study included 198 MBC patients (96 with and 102 without BM). Using
tissue microarrays derived from the primary tumor, we assessed by immunohistochemical
expression of ER, PR, HER2, Ki-67, CK5/6, EGFR, HER3, CXCR4, Rad51, E-cadherin, and …
breast cancer. In this study, we investigated the correlation between expression of selected
proteins in the primary tumor and the risk of BM in patients with metastatic breast cancer
(MBC). Methods The study included 198 MBC patients (96 with and 102 without BM). Using
tissue microarrays derived from the primary tumor, we assessed by immunohistochemical
expression of ER, PR, HER2, Ki-67, CK5/6, EGFR, HER3, CXCR4, Rad51, E-cadherin, and …
Background
There are no clinically useful biomarkers predictive of brain metastases (BM) in breast cancer. In this study, we investigated the correlation between expression of selected proteins in the primary tumor and the risk of BM in patients with metastatic breast cancer (MBC).
Methods
The study included 198 MBC patients (96 with and 102 without BM). Using tissue microarrays derived from the primary tumor, we assessed by immunohistochemical expression of ER, PR, HER2, Ki-67, CK5/6, EGFR, HER3, CXCR4, Rad51, E-cadherin, and claudin 3 and 4.
Results
Ki-67 ≥14% (hazard ratio [HR] 2.76; P < 0.001), cytoplasmic expression of Rad51 (HR 1.87; P = 0.014) and ER-negativity (HR 1.72; P = 0.029) were associated with increased risk of BM in the multivariate analysis. A three-biomarker profile including ER, Ki-67 and Rad51 vs. other subtypes combined yielded an HR of 4.43 (P < 0.001).
Conclusions
ER-negativity, cytoplasmic expression of Rad51 and high Ki-67 are associated with increased risk of BM.
Elsevier