Platelet integrin adhesive functions and signaling

N Prévost, H Kato, L Bodin, SJ Shattil - Methods in enzymology, 2007 - Elsevier
Integrin‐mediated cellular events affect all cell types and functions, in physiological as well
as pathological settings. Blood platelets, because of their unique nature, have proven to be
a powerful cell model with which to study the adhesive and signaling properties of integrins.
The characterization of the structural and molecular mechanisms regulating the main
platelet integrin, αIIbβ3, has provided some essential clues as to how integrins are regulated
in general. The present chapter details the various protocols and reagents currently in use in …