Frameshift mutants of β amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

FW Van Leeuwen, DPV de Kleijn, HH van den Hurk… - Science, 1998 - science.org
FW Van Leeuwen, DPV de Kleijn, HH van den Hurk, A Neubauer, MAF Sonnemans…
Science, 1998science.org
The cerebral cortex of Alzheimer's and Down syndrome patients is characterized by the
presence of protein deposits in neurofibrillary tangles, neuritic plaques, and neuropil
threads. These structures were shown to contain forms of β amyloid precursor protein and
ubiquitin-B that are aberrant (+ 1 proteins) in the carboxyl terminus. The+ 1 proteins were not
found in young control patients, whereas the presence of ubiquitin-B+ 1 in elderly control
patients may indicate early stages of neurodegeneration. The two species of+ 1 proteins …
The cerebral cortex of Alzheimer's and Down syndrome patients is characterized by the presence of protein deposits in neurofibrillary tangles, neuritic plaques, and neuropil threads. These structures were shown to contain forms of β amyloid precursor protein and ubiquitin-B that are aberrant (+1 proteins) in the carboxyl terminus. The +1 proteins were not found in young control patients, whereas the presence of ubiquitin-B+1 in elderly control patients may indicate early stages of neurodegeneration. The two species of +1 proteins displayed cellular colocalization, suggesting a common origin, operating at the transcriptional level or by posttranscriptional editing of RNA. This type of transcript mutation is likely an important factor in the widely occurring nonfamilial early- and late-onset forms of Alzheimer's disease.
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