[HTML][HTML] Structural elucidation of a carnosine-acrolein adduct and its quantification in human urine samples
VS Bispo, IP de Arruda Campos, P Di Mascio… - Scientific Reports, 2016 - nature.com
VS Bispo, IP de Arruda Campos, P Di Mascio, MHG Medeiros
Scientific Reports, 2016•nature.comAldehydes accumulate in inflammation, during myocardial infarction and have been
associated with pain symptoms. One pathway of aldehyde detoxification is the conjugation
with carnosine. A 3-methylpyridinium carnosine adduct from the reaction of carnosine and
acrolein was characterized using extensive spectroscopic measurements. The adduct with
urinary concentrations of 1.82±0.68 nmol/mg of creatinine is one of the most abundant
acrolein metabolites in urine and opens promising therapeutic strategies for carnosine.
associated with pain symptoms. One pathway of aldehyde detoxification is the conjugation
with carnosine. A 3-methylpyridinium carnosine adduct from the reaction of carnosine and
acrolein was characterized using extensive spectroscopic measurements. The adduct with
urinary concentrations of 1.82±0.68 nmol/mg of creatinine is one of the most abundant
acrolein metabolites in urine and opens promising therapeutic strategies for carnosine.
Abstract
Aldehydes accumulate in inflammation, during myocardial infarction and have been associated with pain symptoms. One pathway of aldehyde detoxification is the conjugation with carnosine. A 3-methylpyridinium carnosine adduct from the reaction of carnosine and acrolein was characterized using extensive spectroscopic measurements. The adduct with urinary concentrations of 1.82 ± 0.68 nmol/mg of creatinine is one of the most abundant acrolein metabolites in urine and opens promising therapeutic strategies for carnosine.
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