Common HIV-1 peptide variants mediate differential binding of KIR3DL1 to HLA-Bw4 molecules
L Fadda, GM O'Connor, S Kumar… - Journal of …, 2011 - Am Soc Microbiol
L Fadda, GM O'Connor, S Kumar, A Piechocka-Trocha, CM Gardiner, M Carrington…
Journal of virology, 2011•Am Soc MicrobiolEpidemiological studies have shown the protective effect of KIR3DL1/HLA-Bw4 genotypes
in human immunodeficiency virus type 1 (HIV-1) infection; however, the functional correlates
for the protective effect remain unknown. We investigated whether human leukocyte antigen
(HLA)-Bw4-presented HIV-1 peptides could affect the interaction between the inhibitory
natural killer (NK) cell receptor KIR3DL1 and its ligand HLA-Bw4. Distinct HIV-1 epitopes
differentially modulated the binding of KIR3DL1 to HLA-Bw4. Furthermore, cytotoxic T …
in human immunodeficiency virus type 1 (HIV-1) infection; however, the functional correlates
for the protective effect remain unknown. We investigated whether human leukocyte antigen
(HLA)-Bw4-presented HIV-1 peptides could affect the interaction between the inhibitory
natural killer (NK) cell receptor KIR3DL1 and its ligand HLA-Bw4. Distinct HIV-1 epitopes
differentially modulated the binding of KIR3DL1 to HLA-Bw4. Furthermore, cytotoxic T …
Abstract
Epidemiological studies have shown the protective effect of KIR3DL1/HLA-Bw4 genotypes in human immunodeficiency virus type 1 (HIV-1) infection; however, the functional correlates for the protective effect remain unknown. We investigated whether human leukocyte antigen (HLA)-Bw4-presented HIV-1 peptides could affect the interaction between the inhibitory natural killer (NK) cell receptor KIR3DL1 and its ligand HLA-Bw4. Distinct HIV-1 epitopes differentially modulated the binding of KIR3DL1 to HLA-Bw4. Furthermore, cytotoxic T lymphocyte (CTL) escape mutations within the immunodominant HLA-B57 (Bw4)-restricted Gag epitope TSTLQEQIGW abrogated KIR3DL1 binding to HLA-B57, suggesting that sensing of CTL escape variants by NK cells can contribute to the protective effect of the KIR3DL1/HLA-Bw4 compound genotype.
American Society for Microbiology