[HTML][HTML] Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1)
C Van Rechem, BR Rood, M Touka, S Pinte… - Journal of biological …, 2009 - ASBMB
The tumor suppressor gene HIC1 (Hypermethylated in Cancer 1) that is epigenetically
silenced in many human tumors and is essential for mammalian development encodes a
sequence-specific transcriptional repressor. The few genes that have been reported to be
directly regulated by HIC1 include ATOH1, FGFBP1, SIRT1, and E2F1. HIC1 is thus involved
in the complex regulatory loops modulating p53-dependent and E2F1-dependent cell
survival and stress responses. We performed genome-wide expression profiling analyses to …
silenced in many human tumors and is essential for mammalian development encodes a
sequence-specific transcriptional repressor. The few genes that have been reported to be
directly regulated by HIC1 include ATOH1, FGFBP1, SIRT1, and E2F1. HIC1 is thus involved
in the complex regulatory loops modulating p53-dependent and E2F1-dependent cell
survival and stress responses. We performed genome-wide expression profiling analyses to …