Protein tyrosine phosphatases as wardens of STAT signaling

FD Böhmer, K Friedrich - Jak-stat, 2014 - Taylor & Francis
FD Böhmer, K Friedrich
Jak-stat, 2014Taylor & Francis
Signaling by signal transducers and activators of transcription (STATs) is controlled at many
levels of the signaling cascade. Protein tyrosine phosphatases (PTPs) regulate STAT
activation at several layers, including direct pSTAT dephosphorylation in both cytoplasm and
nucleus. Despite the importance of this regulation mode, many aspects are still incompletely
understood, eg, the identity of PTPs acting on certain members of the STAT family. After a
brief introduction into the STAT and PTP families, we discuss here the current knowledge on …
Signaling by signal transducers and activators of transcription (STATs) is controlled at many levels of the signaling cascade. Protein tyrosine phosphatases (PTPs) regulate STAT activation at several layers, including direct pSTAT dephosphorylation in both cytoplasm and nucleus. Despite the importance of this regulation mode, many aspects are still incompletely understood, e.g., the identity of PTPs acting on certain members of the STAT family. After a brief introduction into the STAT and PTP families, we discuss here the current knowledge on PTP mediated regulation of STAT activity, focusing on the interaction of individual STATs with specific PTPs. Finally, we highlight open questions and propose important tasks of future research.
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