Interaction between HLA-G and monocyte/macrophages in human pregnancy
A Shakhawat, V Shaikly, E Elzatma, E Mavrakos… - Journal of reproductive …, 2010 - Elsevier
Several lines of evidence suggest that the human leukocyte antigen (HLA)-G play a key role
in the regulation of human pregnancy. A sub-population of cells highly represented at the
decidua belong to the myeloid-derived monocyte/macrophage lineage, which potentially
interact with HLA-G expressing cells. It is proposed that HLA-G protects decidual
trophoblasts from lysis by blocking the effector function of decidual monocyte/macrophages.
The interaction between HLA-G and monocyte/macrophages may therefore contribute to a …
in the regulation of human pregnancy. A sub-population of cells highly represented at the
decidua belong to the myeloid-derived monocyte/macrophage lineage, which potentially
interact with HLA-G expressing cells. It is proposed that HLA-G protects decidual
trophoblasts from lysis by blocking the effector function of decidual monocyte/macrophages.
The interaction between HLA-G and monocyte/macrophages may therefore contribute to a …