[HTML][HTML] Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance
H Cheng, F Mohammed, G Nam, Y Chen, J Qi… - Journal of Biological …, 2011 - ASBMB
The myeloid inhibitory receptor LILRB4 (also called ILT3, LIR-5, CD85k), a member of the
leukocyte immunoglobulin-like receptors (LILRs/LIRs), is an important mediator of immune
tolerance. Up-regulated on tolerogenic dendritic cells, it has been shown to modulate
immune responses via induction of T cell anergy and differentiation of CD8+ T suppressor
cells and may play a role in establishing immune tolerance in cancer. Consequently,
characterizing the molecular mechanisms involved in LILRB4 function and in particular its …
leukocyte immunoglobulin-like receptors (LILRs/LIRs), is an important mediator of immune
tolerance. Up-regulated on tolerogenic dendritic cells, it has been shown to modulate
immune responses via induction of T cell anergy and differentiation of CD8+ T suppressor
cells and may play a role in establishing immune tolerance in cancer. Consequently,
characterizing the molecular mechanisms involved in LILRB4 function and in particular its …