Genetics and pathogenesis of inflammatory bowel disease
TC Liu, TS Stappenbeck - Annual Review of Pathology …, 2016 - annualreviews.org
We are currently in an exciting time when our understanding of genetic underpinnings of
inflammatory bowel disease (IBD) has undergone a revolution, based in large part on novel
genotyping and sequencing technologies. With> 160 susceptible loci identified for IBD, the
goal is now to understand at a fundamental level the function of these susceptibility alleles.
Determining the clinical relevance of how these susceptible genes shape the development
of IBD is also a high priority. The main challenge is to understand how the environment and …
inflammatory bowel disease (IBD) has undergone a revolution, based in large part on novel
genotyping and sequencing technologies. With> 160 susceptible loci identified for IBD, the
goal is now to understand at a fundamental level the function of these susceptibility alleles.
Determining the clinical relevance of how these susceptible genes shape the development
of IBD is also a high priority. The main challenge is to understand how the environment and …