Cancer cell and macrophage cross-talk in the tumor microenvironment

N Dehne, J Mora, D Namgaladze, A Weigert… - Current opinion in …, 2017 - Elsevier
Highlights•The tumor microenvironment contains innate immune cells, for example,
macrophages.•Hypoxia imposes stress to tumor cells and their environment.•Tumor cell alter
their intermediary metabolism and communication with macrophages.•The mode of tumor
cell death dictates the macrophage phenotype.Tumors are composed of tumor cells,
nonmalignant cells, and the vascular system. Among them is intense communication via cell–
cell contact-dependent mechanisms and/or soluble messengers. In the tumor …