Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome

SC Donnelly, C Haslett, PT Reid, IS Grant… - Nature medicine, 1997 - nature.com
SC Donnelly, C Haslett, PT Reid, IS Grant, WAH Wallace, CN Metz, LJ Bruce, R Bucala
Nature medicine, 1997nature.com
Migration inhibitory factor (MIF) is known to exert significant pro-inflammatory effects and has
the potential to override the anti-inflammatory action of glucocorticoids. In this study we have
identified significant quantities of MIF in the alveolar airspaces of patients with acute
respiratory distress syndrome (ARDS). We show in alveolar cells from patients with ARDS
that MIF augments pro-inflammatory cytokine secretion (TNFα and IL-8), anti-MIF
significantly attenuates TNFα and IL-8 secretion and MIF overrides, in a concentration …
Abstract
Migration inhibitory factor (MIF) is known to exert significant pro-inflammatory effects and has the potential to override the anti-inflammatory action of glucocorticoids. In this study we have identified significant quantities of MIF in the alveolar airspaces of patients with acute respiratory distress syndrome (ARDS). We show in alveolar cells from patients with ARDS that MIF augments pro-inflammatory cytokine secretion (TNFα and IL-8), anti-MIF significantly attenuates TNFα and IL-8 secretion and MIF overrides, in a concentration-related fashion, the anti-inflammatory effects of glucocorticoids. These findings suggest that MIF may act as a mediator sustaining the pulmonary inflammatory response in ARDS and that an anti-MIF strategy may represent a novel therapeutic approach in inflammatory diseases such as ARDS.
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