Adipose tissue and adipocyte dysregulation

M Lafontan - Diabetes & metabolism, 2014 - Elsevier
Obesity-associated insulin resistance is a complex disorder involving a number of candidate
molecules, pathways and transduction systems possessing potential causal actions.
Inflammation in adipose tissue (AT) is one mechanism proposed to explain the development
of insulin resistance, while identification of factors that lead to or cause AT dysfunction when
it reaches its limit of expansion represents an important challenge. Pathological expansion
of AT is characterized by changes in its blood flow, and the presence of enlarged and …