Olanzapine (LY170053, 2-Methyl-4-(4-methyl-1-piperazinyl)-10 H-thieno [2, 3-b][1, 5] Benzodiazepine), but Not the Novel Atypical Antipsychotic ST2472 (9-Piperazin …
R Coccurello, A Caprioli, R Conti, O Ghirardi… - The Journal of …, 2008 - Elsevier
ABSTRACT A mouse model of atypical antipsychotic-associated adverse effects was used to
compare the liability to induce weight gain, food intake, and metabolic alterations after
chronic olanzapine (OL; LY170053, 2-methyl-4-(4-methyl-1-piperazinyl)-10 H-thieno-[2, 3-
b][1, 5] benzodiazepine) and ST2472 (ST; 9-piperazin-1-ylpyrrolo [2, 1-b][1, 3]
benzothiazepine) administration. By adding two equipotent doses (3 and 6 mg/kg) of either
OL or ST to a high-sweet, high-fat (HS-HF) diet, mice were allowed to self-administer drugs …
compare the liability to induce weight gain, food intake, and metabolic alterations after
chronic olanzapine (OL; LY170053, 2-methyl-4-(4-methyl-1-piperazinyl)-10 H-thieno-[2, 3-
b][1, 5] benzodiazepine) and ST2472 (ST; 9-piperazin-1-ylpyrrolo [2, 1-b][1, 3]
benzothiazepine) administration. By adding two equipotent doses (3 and 6 mg/kg) of either
OL or ST to a high-sweet, high-fat (HS-HF) diet, mice were allowed to self-administer drugs …