Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia

AO Etyang, C Khayeka‐Wandabwa… - Journal of the …, 2017 - Am Heart Assoc
AO Etyang, C Khayeka‐Wandabwa, S Kapesa, E Muthumbi, E Odipo, M Wamukoya…
Journal of the American Heart Association, 2017Am Heart Assoc
Background Recent studies have discovered that α‐globin is expressed in blood vessel
walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood
pressure (BP) might differ between normal individuals and those with α+ thalassemia, in
whom the production of α‐globin is reduced. Methods and Results The study was conducted
in Nairobi, Kenya, among 938 adolescents aged 11 to 17 years. Twenty‐four‐hour
ambulatory BP monitoring and arterial stiffness measurements were performed using an …
Background
Recent studies have discovered that α‐globin is expressed in blood vessel walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood pressure (BP) might differ between normal individuals and those with α+thalassemia, in whom the production of α‐globin is reduced.
Methods and Results
The study was conducted in Nairobi, Kenya, among 938 adolescents aged 11 to 17 years. Twenty‐four‐hour ambulatory BP monitoring and arterial stiffness measurements were performed using an arteriograph device. We genotyped for α+thalassemia by polymerase chain reaction. Complete data for analysis were available for 623 subjects; 223 (36%) were heterozygous (−α/αα) and 47 (8%) were homozygous (−α/−α) for α+thalassemia whereas the remaining 353 (55%) were normal (αα/αα). Mean 24‐hour systolic BP ±SD was 118±12 mm Hg in αα/αα, 117±11 mm Hg in −α/αα, and 118±11 mm Hg in −α/−α subjects, respectively. Mean 24‐hour diastolic BP ±SD in these groups was 64±8, 63±7, and 65±8 mm Hg, respectively. Mean pulse wave velocity (PWV)±SD was 7±0.8, 7±0.8, and 7±0.7 ms−1, respectively. No differences were observed in PWV and any of the 24‐hour ambulatory BP monitoring‐derived measures between those with and without α+thalassemia.
Conclusions
These data suggest that the presence of α+thalassemia does not affect BP and/or arterial stiffness in Kenyan adolescents.
Am Heart Assoc