Conserved and divergent features of mesenchymal progenitor cell types within the cortical nephrogenic niche of the human and mouse kidney

NO Lindström, J Guo, AD Kim, T Tran… - Journal of the …, 2018 - journals.lww.com
Cellular interactions among nephron, interstitial, and collecting duct progenitors drive
mammalian kidney development. In mice, Six2+ nephron progenitor cells (NPCs) and
Foxd1+ interstitial progenitor cells (IPCs) form largely distinct lineage compartments at the
onset of metanephric kidney development. Here, we used the method for analyzing RNA
following intracellular sorting (MARIS) approach, single-cell transcriptional profiling, in situ
hybridization, and immunolabeling to characterize the presumptive NPC and IPC …