The relative inefficiency of respiratory mucosal immune function during infancy is generally
attributed to the immaturity of the neonatal T cell system. However, immune competence in
the adult lung has recently been shown to be closely linked to the functional capacity of local
networks of intraepithelial dendritic cells (DC). This study examines the density and
distribution of these DC throughout the neonatal respiratory tract in rats, focusing particularly
on microenvironmental regulation of their class II major histocompatibility complex (MHC)(Ia) …

Development of the airway intraepithelial dendritic cell network in the rat from class II MHC (Ia)
negative precursors: differential regulation of Ia expression at different levels of the respiratory
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