Recombination signal binding protein for Ig-κJ region regulates juxtaglomerular cell phenotype by activating the myo-endocrine program and suppressing ectopic …
RM Castellanos-Rivera, ES Pentz, E Lin… - Journal of the …, 2015 - journals.lww.com
Recombination signal binding protein for Ig-κJ region (RBP-J), the major downstream
effector of Notch signaling, is necessary to maintain the number of renin-positive
juxtaglomerular cells and the plasticity of arteriolar smooth muscle cells to re-express renin
when homeostasis is threatened. We hypothesized that RBP-J controls a repertoire of genes
that defines the phenotype of the renin cell. Mice bearing a bacterial artificial chromosome
reporter with a mutated RBP-J binding site in the renin promoter had markedly reduced …
effector of Notch signaling, is necessary to maintain the number of renin-positive
juxtaglomerular cells and the plasticity of arteriolar smooth muscle cells to re-express renin
when homeostasis is threatened. We hypothesized that RBP-J controls a repertoire of genes
that defines the phenotype of the renin cell. Mice bearing a bacterial artificial chromosome
reporter with a mutated RBP-J binding site in the renin promoter had markedly reduced …