Dose effects of propranolol on cancellous and cortical bone in ovariectomized adult rats
N Bonnet, N Laroche, L Vico, E Dolleans… - The Journal of …, 2006 - Elsevier
Animal studies suggest that bone remodeling is under β-adrenergic control via the
sympathetic nervous system. The purpose of this study was to examine the preventive effect
of different doses of nonspecific β-blockers (propranolol) on trabecular and cortical bone
envelopes in ovariectomized rats. Six-month-old female Wistar rats were ovariectomized
(OVX, n= 60) or sham-operated (n= 15). Then, OVX rats were subcutaneously injected with
0.1 (n= 15), 5 (n= 15), or 20 (n= 15) mg/kg propranolol or vehicle (n= 15) for 10 weeks. Tibial …
sympathetic nervous system. The purpose of this study was to examine the preventive effect
of different doses of nonspecific β-blockers (propranolol) on trabecular and cortical bone
envelopes in ovariectomized rats. Six-month-old female Wistar rats were ovariectomized
(OVX, n= 60) or sham-operated (n= 15). Then, OVX rats were subcutaneously injected with
0.1 (n= 15), 5 (n= 15), or 20 (n= 15) mg/kg propranolol or vehicle (n= 15) for 10 weeks. Tibial …