[HTML][HTML] DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA
A Ordureau, K Enesa, S Nanda, B Le Francois… - Journal of Biological …, 2013 - ASBMB
Double-stranded (ds) RNA of viral origin, a ligand for Melanoma Differentiation-associated
gene 5 (MDA5) and Toll-Like Receptor 3 (TLR3), induces the TANK-Binding Kinase 1
(TBK1)-dependent phosphorylation and activation of Interferon Regulatory Factor 3 (IRF3)
and the E3 ubiquitin ligase Pellino1, which are required for interferon β (IFNβ) gene
transcription. Here, we report that Pellino1 interacts with the transcription factor Deformed
Epidermal Autoregulatory Factor 1 (DEAF1). The interaction is independent of the E3 ligase …
gene 5 (MDA5) and Toll-Like Receptor 3 (TLR3), induces the TANK-Binding Kinase 1
(TBK1)-dependent phosphorylation and activation of Interferon Regulatory Factor 3 (IRF3)
and the E3 ubiquitin ligase Pellino1, which are required for interferon β (IFNβ) gene
transcription. Here, we report that Pellino1 interacts with the transcription factor Deformed
Epidermal Autoregulatory Factor 1 (DEAF1). The interaction is independent of the E3 ligase …