[HTML][HTML] Novel evolutionary-conserved role for the activity-dependent neuroprotective protein (ADNP) family that is important for erythropoiesis
E Dresner, A Malishkevich, C Arviv, SL Barak… - Journal of Biological …, 2012 - ASBMB
Activity-dependent neuroprotective protein (ADNP) and its homologue ADNP2 belong to a
homeodomain, the zinc finger-containing protein family. ADNP is essential for mouse
embryonic brain formation. ADNP2 is associated with cell survival, but its role in
embryogenesis has not been evaluated. Here, we describe the use of the zebrafish model to
elucidate the developmental roles of ADNP and ADNP2. Although we expected brain
defects, we were astonished to discover that the knockdown zebrafish embryos were …
homeodomain, the zinc finger-containing protein family. ADNP is essential for mouse
embryonic brain formation. ADNP2 is associated with cell survival, but its role in
embryogenesis has not been evaluated. Here, we describe the use of the zebrafish model to
elucidate the developmental roles of ADNP and ADNP2. Although we expected brain
defects, we were astonished to discover that the knockdown zebrafish embryos were …