ADNP: A major autism mutated gene is differentially distributed (age and gender) in the songbird brain
G Hacohen-Kleiman, A Barnea, I Gozes - Peptides, 2015 - Elsevier
ADNP is a protein necessary for brain development, important for brain plasticity, cognitive
and social functioning, characteristics that are all impaired in autism and in the Adnp+/−
mouse model, in a sex-dependent manner. ADNP was originally discovered as a protein
that is secreted from glial cells in response to vasoactive intestinal peptide (VIP). VIP is a
major neuroprotective peptide in the CNS and PNS and was also associated with social
recognition in rodents and aggression, pair-bonding and parental behaviors in birds …
and social functioning, characteristics that are all impaired in autism and in the Adnp+/−
mouse model, in a sex-dependent manner. ADNP was originally discovered as a protein
that is secreted from glial cells in response to vasoactive intestinal peptide (VIP). VIP is a
major neuroprotective peptide in the CNS and PNS and was also associated with social
recognition in rodents and aggression, pair-bonding and parental behaviors in birds …