[HTML][HTML] Cloning and characterization of the human activity-dependent neuroprotective protein
R Zamostiano, A Pinhasov, E Gelber… - Journal of Biological …, 2001 - ASBMB
We have recently cloned the mouse activity-dependent neuroprotective protein (ADNP).
Here, we disclose the cloning of human ADNP (hADNP) from a fetal brain cDNA library.
Comparative sequence analysis of these two ADNP orthologs indicated 90% identity at the
mRNA level. Several single nucleotide polymorphic sites were noticed. The deduced protein
structure contained nine zinc fingers, a proline-rich region, a nuclear bipartite localization
signal, and a homeobox domain profile, suggesting a transcription factor function. Further …
Here, we disclose the cloning of human ADNP (hADNP) from a fetal brain cDNA library.
Comparative sequence analysis of these two ADNP orthologs indicated 90% identity at the
mRNA level. Several single nucleotide polymorphic sites were noticed. The deduced protein
structure contained nine zinc fingers, a proline-rich region, a nuclear bipartite localization
signal, and a homeobox domain profile, suggesting a transcription factor function. Further …