SLE nephritis is associated with an oligoclonal expansion of intrarenal T cells
SF Massengill, MM Goodenow, JW Sleasman - American journal of kidney …, 1998 - ajkd.org
Autoimmune systemic lupus erythematosus (SLE) nephritis is characterized by the influx of
mononuclear inflammatory cell infiltrates within the glomeruli and renal interstitium. To
evaluate the possibility that intrarenal T cells result from the expansion of lymphocytes using
limited T-cell receptor (TCR) genes, we analyzed the TCR Vbeta gene expression among
infiltrating lymphocytes in renal tissue compared with simultaneous peripheral blood
lymphocytes of four children with new-onset SLE nephritis. The TCR Vbeta gene expression …
mononuclear inflammatory cell infiltrates within the glomeruli and renal interstitium. To
evaluate the possibility that intrarenal T cells result from the expansion of lymphocytes using
limited T-cell receptor (TCR) genes, we analyzed the TCR Vbeta gene expression among
infiltrating lymphocytes in renal tissue compared with simultaneous peripheral blood
lymphocytes of four children with new-onset SLE nephritis. The TCR Vbeta gene expression …