[PDF][PDF] Tumor dissemination: an EMT affair

JP Thiery, CT Lim - Cancer cell, 2013 - cell.com
Cancer cell, 2013cell.com
A recent paper reports that circulating tumor cells (CTCs) from metastatic breast cancer
patients exhibit heterogeneous epithelial and mesenchymal phenotypes and that CTCs
display higher frequencies of partial or full-blown mesenchymal phenotype than carcinoma
cells within primary tumors. Mesenchymal-like CTCs are also elevated in patients who are
refractory to therapy.
A recent paper reports that circulating tumor cells (CTCs) from metastatic breast cancer patients exhibit heterogeneous epithelial and mesenchymal phenotypes and that CTCs display higher frequencies of partial or full-blown mesenchymal phenotype than carcinoma cells within primary tumors. Mesenchymal-like CTCs are also elevated in patients who are refractory to therapy.
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