Why is placentation abnormal in preeclampsia?

SJ Fisher - American journal of obstetrics and gynecology, 2015 - Elsevier
The causes of preeclampsia remain one of the great medical mysteries of our time. This
syndrome is thought to occur in 2 stages with abnormal placentation leading to a maternal
inflammatory response. Specific regions of the placenta have distinct pathologic features.
During normal pregnancy, cytotrophoblasts emigrate from the chorionic villi and invade the
uterus, reaching the inner third of the myometrium. This unusual process is made even more
exceptional by the fact that the placental cells are hemiallogeneic, coexpressing maternal …