Drug repurposing screen identifies Foxo1-dependent angiopoietin-2 regulation in sepsis

CC Ghosh, K Thamm, AV Berghelli… - Critical care …, 2015 - journals.lww.com
Objective: The recent withdrawal of a targeted sepsis therapy has diminished
pharmaceutical enthusiasm for developing novel drugs for the treatment of sepsis.
Angiopoietin-2 is an endothelial-derived protein that potentiates vascular inflammation and
leakage and may be involved in sepsis pathogenesis. We screened approved compounds
for putative inhibitors of angiopoietin-2 production and investigated underlying molecular
mechanisms. Design: Laboratory and animal research plus prospective placebo-controlled …